Diabetes and its treatment
Diabetes Mellitus: – often referred simply as Diabetes is a common disease. Diabetes is a metabolic disorder wherein, the human body is not in the condition to produce enough or does not properly utilize the insulin, a hormone produced in the pancreas which enables cells to absorb glucose in order to turn it into energy. In diabetes, the body either fails to properly respond to its own insulin, does not make enough insulin or both.
This causes glucose to accumulate in the blood, often leading to various complications. Diabetes Mellitus is characterized by constant high levels of blood glucose (sugar). Human body has to maintain the blood glucose level at a very narrow range, which is done with insulin and glucagons. The function of glucagons is causing the liver to release glucose from its cells into the blood, for the production of energy. There are many types of diabetes. The principal three are:
• Type 1 Diabetes – Results from the body’s failure to produce insulin.
• Type 2 Diabetes – Results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with relative insulin deficiency.
• Gestational Diabetes – Pregnant women who have never had diabetes before but who have high blood sugar (glucose) levels during pregnancy are said to have gestational diabetes. Gestational diabetes affects about 4% of all pregnant women. It may precede development of type 2 (or rarely type 1).
• Many other forms of diabetes mellitus are categorized separately from these. Examples include congenital diabetes due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids (Glucocorticoids are a class of steroid hormones that bind to the glucocorticoid receptor, which is present in almost every vertebrate animal cell.), and several forms of Monogenic Diabetes.
Type 1 and Type 2 Diabetes obstruct a person’s carefree life. When breaking down of glucose in the body is stopped completely, it takes the help of fat and protein to produce the energy, due to which symptoms like polydipsia, polyuria, polyphegia, excessive weight loss etc is noticed in a diabetic. Normal blood sugar level in a human body is between 70 mg/dl to 110 mg/dl at fasting state. If blood sugar level is lower than 70 mg/dl, it is termed as hypoglycemia and if it is higher than 110 mg/dl, it is termed as hyperglycemia. Though all forms of diabetes have become treatable since 1921 because of the availability of Insulin, it’s not fully curable except a pancreas transplant, although gestational diabetes normally resolves after delivery. Acute complications in diabetes include hypoglycemia, diabetic ketoacidosis or nonketotic hyperosmdar coma which may occur if the disease isn’t treated or properly controlled. Serious long term includes cardiovascular disease, chronic renal failure, and retinal damage leading to blindness, nerve failure, erectile dysfunction and poor wound healing, which, particularly of the feet may cause gangrene, possibly requiring amputation.
Proper and adequate treatment of diabetes as well as increased emphasis and special care about the increased blood pressure and life style factors such as not smoking, having a healthy and fit body may improve the risk profile of most of the chronic complications. Over weight, lack of exercise, family history, stress etc increase the risk of diabetes. Diabetes is the most significant cause of adult blindness in the non elderly and the leading cause of non traumatic amputation in adults.
Author: Amrita Lahiri