Alzheimer’s disease and its Symptoms
Alzheimer’s disease is an incurable and degenerative brain disease. It is one form of dementia in which brain tissue degenerates causing steady decline in brain functions. The disease is named after Dr. Alois Alzheimer’s, who first described it in 1906. He was a German physician.
Alzheimer’s disease causes memory loss, affects thinking skills and behavior. About 100 billions of nerve cells known as neurons are there in human brain. Each is connected with the other in a complex network. Human brain controls memory consciousness, vision, thinking and many activities through this complex network of neurons. Neurons communicate with each other through certain chemicals known as neurotransmitters. This disease i.e. Alzheimer’s disease is characterized by loss of nerve cells (neurons) and synapses in cerebral cortex region and some sub cortical regions.
How neurons die
Formation of abnormal structures like amyloid plaques and tangles (neurofibrillary tangles) inside brain lead to destruction of neurons.
Plaques are hard, insoluble deposits of protein fragment called beta-amyloid. Tangles which are insoluble twisted fibres of another protein called ‘tan’ accumulate inside the cells themselves. These abnormal deposits prevent normal brain cells to send right signals to other part of brain.
In Alzheimer’s disease as more and more plaques and tangles develop in particular areas of brain, more and more neurons gradually loose their efficiency to function and communicate with each other and ultimately they die. Affected brain region begin to shrink due to the death of increasing number of neurons.
Symptoms of Alzheimer’s disease
Initial stage: -
People with Alzheimer’s disease
- May find disturbances in short term memory, memory begins to fade.
- May find language problems: – Facing trouble in finding names of objects which are familiar.
- May not show any interest in things which previously enjoyed.
- May misplace things.
- May take much time to than usual to finish routine work.
- May loose ability and find difficulty in performing task – paying bills, managing money.
- May loose social skills.
- May have changes in mood and personality.
Middle Stage:-
- Find trouble to recognize familiar faces.
- Memories of present confused with distant past.
- Face difficulty in reading and writing.
- Face problems in pronunciation, use wrong words and speak in confusing sentence.
- Poor judgment.
- May become depressed.
- May agitate, may become violent.
- No interest in social contact, withdrawal from social contact.
- Change of sleep pattern may wake up at night.
- Problems in eating, dressing.
Final Stage: -
- May loose ability to recognize people.
- May loose ability to speak.
- May loose ability to feed themselves and control bodily functions.
- May require constant care.
Author: Surya Narayan Bhattacharya
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